Nnsynthesis reactivity and biological activity of benzimidazole pdf

Coordination behavior of benzimidazole, 2substituted. Synthesis and biological activity of novel benzimidazoles. Synthesis and biological activity of benzimidazole5carboxamides. The pharmacological activities of the benzimidazole containing moiety have been well. Benzimidazole is a heterocyclic aromatic organic compound. Synthesis and pharmacological evaluation of new benzimidazole derivatives srinivas bethi, matta vidyasagar, rajamanohar. However, owing to fast developing benzimidazole containing new drugs numerous reports have appeared on the synthesis of this privileged scaffold. Synthesis and medicinal applications of benzimidazoles. In 1991 benzimidazole derivatives were synthesized by derivatization at nh of benzimidazole by electron donating group and substitution with long chain of propyl, acetamido, thio, thiazoleamino, tetramethyl piperidine on pyridine resulting in good antiulcer activity 2,3. Syntheses of quinoxaline derivatives via many different methods of synthetic strategies have been presented. Synthesis and antimicrobial activity of some compounds containing benzimidazole nucleus a.

The five membered heterocyclic moieties also confer for various biological activities. Synthesis, characterization and biological studies of some. It is a tautomer of a 4hbenzimidazole, a 2hbenzimidazole and a 3ahbenzimidazole. New synthetic procedures, including microwaveassisted synthesis, solid phase synthesis, natural product synthesis, and synthesis of bisbenzimidazoles are briefly described. Synthesis of some new nucleosides derived from 2 mercapto. Salman department of chemistry, faculty of science, girls branch, alazhar university, nasr city, cairo, egypt. Benzimidazole is a heterocyclic aromatic organic compound which has been an important pharmacophore and privileged structure in medicinal chemistry.

Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, antiinflammatory, analgesic, etc. Synthesis and anthelmintic activity of benzimidazole. In the first step, benzimidazole 2 was synthesized from o phenylenediamine and formic acid by the ring closure reaction with a loss of two water molecules. Hence, it was thought of interest to merge both of benzimidazole and oxadiazole moieties which may enhance the drug activity of compounds to some extent, or they might possess some of the above mentioned. Synthesis, characterization, and microwavepromoted catalytic activity of. Specifically, this nucleus is a constituent of vitamin b 12 oneil et al. Oxygen and sulphur containing heterocyclic have appeared owing to a wide variety of their biological activity. Substituted benzimidazole derivatives have found commercial application in veterinarian medicine as anthelmintic agents and in diverse human therapeutic pharm chemistry synthesis, characterization, and biological evaluation of benzimidazole derivatives as potential anxiolytics nannapaneni dt, gupta atyam vsss1, reddy mi, sarva raidu ch1. Anti bacterial activity were screened against staphylococcus aureus.

There is a growing interest over the past years for the synthesis of benzimidazolebased heterocycles due to the crucial role of benzimidazole unit in the functions of biologically important molecules. Benzimidazole derivatives are considered as a promising class of biologically active heterocyclic compounds that show a wide of biological activities like anti. Synthesis of phenyl hydrazine substituted benzimidazole. Pharmacological compounds of benzimidazole derivatives are potent inhibitors for a variety of enzymes. The yield of all benzimidazole derivatives were found to be in the range of 75 94%. Condensation of ophenylene diamine with chloro acetic acid gave 2chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding nn. Synthesis, antimicrobial and anthelmintic activity of some. Structureactivity relationships of benzimidazole derivatives as antiparasitic agents. Sravya department of pharmaceutical chemistry, geethanjali college of pharmacy, cheeryalv, keesaram, hyderabad. As a result of the biological activity exhibited by the heterocyclic molecules, the development of new. Benzimidazole derivatives have shown hopeful activity in the treatment of several diseases, for this reason, the synthesis of novel benzimidazole remains a main focus for researchers. Hence a series of benzimidazole derivatives have been synthesized characterized by uv, ir and 1h nmr spectral data and evaluated for their and in vitro antioxidant activity.

A class of antihelmintic, often used to treat nematodes and cestodes. Nevertheless, the research concerned with the biological activity of coordination compounds. Benzimidazole, a heterocyclic aromatic organic compound consisting of a fusion of benzene and imidazole, in an extension of the wellelaborated imidazole system, has been used as a carbon skeleton for n heterocyclic carbenes, usually used as ligand for transition metal complexes. A onepot, multicomponent reaction enables the transformation of commercial aryl amines, aldehydes, and azides into valuable benzimidazole structural units with wide substrate scope and diversity via an efficient coppercatalyzed amination of naryl imines, in which imine acts as a directing group by chelating to the metal center. The benzimidazole and its derivatives play a very important role as a therapeutic agent e. Synthesis and biological activity of benzimidazole5. Benzimidazole nucleus is one of the bioactive heterocyclic compounds that exhibit a range of biological activities. In the next step, compound 2 was treated with p aminoacetophenone and formaldehyde results in the corresponding mannich base 3 by the mannich reaction. Gcms analysis gcms spectra were recorded on an agilient 6890 n gc and 5973 mass selective detector with an hp. In the present study, a series of novel benzimidazole derivatives containing chrysanthemum acid moieties was designed and synthesized. Synthesis and biological activity of novel benzimidazole. Designing and biological evaluation of new benzimidazole compounds ch. The synthesized compounds were subjected to microbiological screening and invitro antiinflammatory activity.

Jcprc5 505 the chemistry and biological significance of imidazole, benzimidazole. Biological activity the newly synthesized compounds 2,4,5,8 and 11. Synthetic routes to benzimidazolebased fused polyheterocycles. Preliminary investigation of biological activity indicated that all of the compounds exhibited lower activity than that of betacypermethrin against plutella xylostella and lipaphis erysimi. Pharmacological activities benzoxazole is an aromatic organic compound with a molecular formula c7h5no, a benzene fused oxazole ring structure, and an odour similar to pyridine. Synthesis of benzimidazole 2 benzimidazole was prepared according to the reported literature. Benzimidazole and their derivatives were reported to have wide biological activities like antitumor, antiviral, antifungal, antioxidant, antiulcer, antiamoebic, antihistaminic, anthelmintic and anti hypertensive activity. Synthesis, characterization, and biological evaluation of. Oxdiazole compounds have shown biological activity against parasites15 and bacteria16,17 and also presence of mannich base side. Synthesis, reactivity and biological activity of benzimidazoles. The present study describes a simple, inexpensive, and easy method for synthesis of benzimidazole derivatives in a stipulated time, without using any drastic conditions.

Synthesis and antimicrobial studies of novel benzimidazole. The purity of the compounds were ascertained by a melting point and tlc. Benzimidazoles heterocyclic building blocks sigmaaldrich. The resulting solution was cooled and made alkaline to litmus with 10% sodium hydroxide solution. The overall reactivity of imidazoles and benzimidazole is referred from sets of resonance structure in which the dipolar contributors have finite importance. Moreover, appearance, orientation and optimization of biological properties of chalcones depend namely on three structural elements. Experimental procedure a series of nsubstituted benzimidazole derivatives were synthesized to determining their analgesic activity. Substituted benzimidazoles have considerable interest as compounds with a wide spectrum of biological activity and low toxicity. Synthesis and analgesic activity evaluation of some new.

These predict electrophilic attack in imidazole at n3 or any ring carbon atom, nucleophilic attack at c2 or c1 and also the amphoteric nature of the molecule. Antiinflammatory synthesis and antiinflammatory activity of phenyl benzimidazole 1 was reported by leonardo et al 6. Benzimidazole derivatives play an important role in medical field with so many pharmacological activities such as antimicrobial, antiviral, antidiabetic and anticancer activity 18. Synthesis, characterization and antimicrobial activity of. Abstract benzimidazole, a physiologically active nucleus, has attracted the attention of many researchers from the point of its chemistry and biological activity. It is a benzimidazole and a polycyclic heteroarene. Benzimidazole derivatives possess various biological activities and the optimization of benzimidazolebased structures has resulted in various drugs that are currently in the market, including omeprazole proton pump inhibitor, pimobendan ionodilator. Synthesis and antimicrobial activity of some 2substituted benzimidazole analogs. Quinoxalines and fused ring systems show diverse pharmacological activities. Synthesis, characterization, and microwavepromoted. Synthesis and antimicrobial activity of some compounds. The new nsubstituted benzimidazole derivatives were synthesized from benzimidazole and benzoyl chloride to produce. Eisa et alsynthesis and antimicrobial activity of benzimidazole derivatives 1517 of the cyclized structure was obtained from the absence of ester band in ir, and by 1h nmr, mass spectrometry and elemental analysis scheme ii. A ring system composed of a benzene ring fused with an imidazole ring.

Benzimidazole and imidazole inhibitors of histone deacetylases. Finally, the key intermediate 16 was alkylated with benzyl chloride in aqueous sodium hydroxide. Pulla reddy college of pharmacy, mehdipatnam, hyderabad 500. Benzimidazole definition of benzimidazole by medical. Synthesis and biological screening of benzimidazole derivatives html full text.